ISFET?based sensors for (bio)chemical applications: A review

Ion-sensitive field effect transistor (ISFET) sensor is a hot topic these years, playing the combined roles of signal recognizer and converter for (bio)chemical analytes. In this review article, basic concept, origination, history ISFET are presented. addition, common fabrication processes, most-used working principle (potentiometric, amperometric, impedancemetric), techniques gate functionality (physical, chemical, biological) discussed introducing afterward transfer processes from to terminals through different types circuits. At last, development recent progress (until 2021) ions biomolecules (DNA molecules, antibodies, enzymatic substrates, cell-related secretions or metabolism) were introduced together with outlook facing obstacles (Debye screening, wearability ISFET, multiplexed detections) before commercialization ISFET. This article emphasizes advantages developed sensors as miniaturization, low-cost, all-solid, highly sensitive, easy operation portable detections.